Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats.

نویسندگان

  • T Yokoyama
  • T Kitazawa
  • A Ishii
  • T Ogihara
  • N Sato
  • A Karasawa
چکیده

We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.

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عنوان ژورنال:
  • Japanese journal of pharmacology

دوره 65 2  شماره 

صفحات  -

تاریخ انتشار 1994